Warnings/Precautions

Lotensin should not be taken by people with a known allergy to ACE inhibitors. Swelling of the facial tissues and even the upper airways has been reported with ACE inhibitors on very rare occasions, and can lead to serious breathing difficulties. Lotensin can interact with diuretics (water pills) and other blood pressure medicines to cause an excessive drop in blood pressure, which can result in symptoms of weakness, dizziness, and lightheadedness. Worsening of kidney function has been reported with ACE inhibitors, especially in patients with severe heart failure or pre-existing kidney disease. Combining lotensin with potassium supplements, potassium containing salt substitutes, and potassium conserving diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of potassium. Indomethacin (Indocin) and possibly other anti-inflammatory medications may decrease the blood pressure lowering effect of lotensin. In rare instances, low white blood cell counts have been reported with the use of another ACE inhibitor. Low white blood cells increase the patient's risk of infections. When taken with lithium, lotensin can increase lithium to toxic levels in the blood. Safe use in children is not established. It is not habit forming. ACE inhibitors, including lotensin, can be harmful to the fetus and should not be taken by pregnant women.